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Nuclear Chemistry & Engineering

Heather Colburn

Pacific Northwest National Laboratory
PO Box 999
Richland, WA 99352

PNNL Publications


  • Ozanich RM, HA Colburn, KD Victry, RA Bartholomew, JS Arce, A Heredia-Langner, KH Jarman, HW Kreuzer, and CJ Bruckner-Lea. 2017. "Evaluation of PCR Systems for Field Screening of Bacillus anthracis." Health Security 15(1):70-80.  doi:10.1089/hs.2016.0043


  • Straub TM, DR Call, CJ Bruckner-Lea, HA Colburn, CL Baird, RA Bartholomew, RM Ozanich, and KH Jarman. 2016. "Field application of pathogen detection technologies." Chapter 2.3.4 in Manual of Environmental Microbiology 4th edition, ed. Yates, MVNo publisher listed doi:10.1128/9781555818821.ch2.3.4



  • Seiner DR, HA Colburn, CL Baird, RA Bartholomew, TM Straub, KD Victry, JR Hutchison, NB Valentine, and CJ Bruckner-Lea. 2013. "Evaluation of the FilmArray® system for detection of Bacillus anthracis, Francisella tularensis, and Yersinia pestis." Journal of Applied Microbiology 114(4):992-1000.  doi:10.1111/jam.12107
  • Straub TM, CL Baird, RA Bartholomew, HA Colburn, DR Seiner, KD Victry, L Zhang, and CJ Bruckner-Lea. 2013. "Estimated Copy Number of Bacillus anthracis Plasmids pXO1 and pXO2 using Digital PCR." Journal of Microbiological Methods 92(1):9-10.  doi:10.1016/j.mimet.2012.10.013


  • Baird CL, DR Seiner, RM Ozanich, RA Bartholomew, HA Colburn, TM Straub, and CJ Bruckner-Lea. 2012. Biodetection Technologies for First RespondersPNNL-21713, Pacific Northwest National Laboratory, Richland, WA. 
  • Wunschel DS, AM Melville, CJ Ehrhardt, HA Colburn, KD Victry, KC Antolick, JH Wahl, and KL Wahl. 2012. "Integration of Gas Chromatography Mass Spectrometry Methods for Differentiating Ricin Preparation Methods." The Analyst 137(9):2077-2085. 


  • Colburn HA, DS Wunschel, KC Antolick, AM Melville, and NB Valentine. 2011. "The Effect of Growth Medium on B. anthracis Sterne Spore Carbohydrate Content." Journal of Microbiological Methods 85(3):183-189.  doi:10.1016/j.mimet.2011.02.015
  • Fraga CG, GA Perez Acosta, MD Crenshaw, K Wallace, GM Mong, and HA Colburn. 2011. "Impurity Profiling to Match a Nerve Agent to Its Precursor Source for Chemical Forensics Applications." Analytical Chemistry 83(4):9564-9572.  doi:10.1021/ac202340u
  • Wunschel DS, KL Wahl, AM Melville, CM Sorensen, HA Colburn, NB Valentine, and CL Stamper. 2011. "Determination of Post-Culture Processing with Carbohydrates by MALDI-MS and TMS derivatization GC/MS." Talanta 85(5):2352-2360.  doi:10.1016/j.talanta.2011.07.073


  • Colburn HA, DS Wunschel, HW Kreuzer-Martin, JJ Moran, KC Antolick, and AM Melville. 2010. "Analysis of Carbohydrate and Fatty Acid Marker Abundance in Ricin Toxin Preparations for Forensic Information." Analytical Chemistry 82(14):6040-6047. 
  • Kreuzer-Martin HW, JH Wahl, CN Metoyer, HA Colburn, and KL Wahl. 2010. "Detection of Acetone Processing of Castor Bean Mash for Forensic Investigation of Ricin Preparation Methods ." Journal of Forensic Sciences 55(4):908-914. 
  • Wahl KL, HA Colburn, DS Wunschel, CE Petersen, KH Jarman, and NB Valentine. 2010. "Residual Agar Determination in Bacterial Spores by Electrospray Ionization Mass Spectrometry ." Analytical Chemistry 82(4):1200-1206. 


  • Grate JW, MG Warner, RM Ozanich, KD Miller, HA Colburn, BP Dockendorff, KC Antolick, NC Anheier, Jr, MA Lind, J Lou, JD Marks, and CJ Bruckner-Lea. 2009. "Renewable Surface Fluorescence Sandwich Immunoassay Biosensor for Rapid Sensitive Botulinum Toxin Detection in an Automated Fluidic Format." Analyst 134(5):987 - 996.  doi:10.1039/B900794F
  • Wahl JH, and HA Colburn. 2009. Solvent Extraction of Chemical Attribution Signature Compounds from Painted Wall Board: Final Report PNNL-18931, Pacific Northwest National Laboratory, Richland, WA. 
  • Wunschel DS, BJM Webb-Robertson, CW Frevert, SJ Skerret, N Beagley, AR Willse, HA Colburn, and KC Antolick. 2009. "Differentiation of Gram-Negative Bacterial Aerosol Exposure Using Detected Markers in Bronchial-Alveolar Lavage Fluid." PLoS One 4(9):e7047.  doi:10.1371/journal.pone.0007047
  • Wunschel DS, HW Kreuzer-Martin, KC Antolick, HA Colburn, JJ Moran, and AM Melville. 2009. ANALYSIS OF RICIN TOXIN PREPARATIONS FOR CARBOHYDRATE AND FATTY ACID ABUNDANCE AND ISOTOPE RATIO INFORMATIONPNNL-19064, Pacific Northwest National Laboratory, Richland, WA. 


  • Jarman KH, HW Kreuzer-Martin, DS Wunschel, NB Valentine, JB Cliff, CE Petersen, HA Colburn, and KL Wahl. 2008. "Bayesian Integrated Microbial Forensics." Applied and Environmental Microbiology 74(11):3573-3582.  doi:10.1128/AEM.02526-07
  • Wunschel DS, HA Colburn, A Fox, KF Fox, WM Harley, JH Wahl, and KL Wahl. 2008. "Detection of Agar, by Analysis of Sugar Markers, Associated with Bacillus Anthracis Spores, After Culture." Journal of Microbiological Methods 74(2-3):57-63. 


  • Ozanich RM, KC Antolick, CJ Bruckner-Lea, BP Dockendorff, AN Easterday, HC Edberg, JW Grate, S Iyer, LH Johnson, TM Straub, CO Valdez, and MG Warner. 2007. "Use of a Novel Fluidics Microbead Trap/Flow-cell Enhances Speed and Sensitivity of Bead-Based Bioassays." JALA. Journal of the Association for Laboratory Automation 12(5):303-310.  doi:10.1016/j.jala.2007.05.002

Nuclear Chemistry & Engineering

Additional Information

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Karl Pool
Analytical Support Operations Lead

Don Bachand
RPL R&D Operations Manager